Optogenetic tools were originally designed to target specific neurons for remote control of their activity by light and have largely been built around opsin-based channels and pumps. These naturally photosensitive opsins are microbial in origin and are unable to mimic the properties of native neuronal receptors and channels. Over the last 8...
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April 13, 2013 (v1)Journal articleUploaded on: February 28, 2023
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August 2019 (v1)Journal article
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December 2019 (v1)Journal article
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September 1, 2011 (v1)Journal article
K+ channels with two-pore domain (K2p) form a large family of hyperpolarizing channels. They produce background currents that oppose membrane depolarization and cell excitability. They are involved in cellular mechanisms of apoptosis, vasodilatation, anesthesia, pain, neuroprotection and depression. This review focuses on TREK-1, TREK-2 and...
Uploaded on: December 3, 2022 -
February 8, 2011 (v1)Journal article
TREK channels produce background currents that regulate cell excitability. These channels are sensitive to a wide variety of stimuli including polyunsaturated fatty acids (PUFAs), phospholipids, mechanical stretch, and intracellular acidification. They are inhibited by neurotransmitters, hormones, and pharmacological agents such as the...
Uploaded on: December 3, 2022 -
2019 (v1)Journal article
Migraine is a common, disabling neurological disorder with genetic, environmental and hormonal components and a prevalence estimated at ∼15%. Migraine episodes are notably related, among several factors, to electric hyperexcitability in sensory neurons. Their electrical activity is controlled by ion channels that generate current, specifically...
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August 25, 2009 (v1)Journal article
Mechanosensitive K(+) channels TREK1 and TREK2 form a subclass of two P-domain K(+) channels. They are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia, and pain perception. Here, we show that acidification of the extracellular medium strongly inhibits TREK1 with an apparent pK near to 7.4...
Uploaded on: December 3, 2022 -
June 21, 2012 (v1)Journal article
Selective ligands are lacking for many neuronal signaling proteins. Photoswitched tethered ligands (PTLs) have enabled fast and reversible control of specific proteins containing a PTL anchoring site and have been used to remote control overexpressed proteins. We report here a scheme for optical remote control of native proteins using a...
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July 1, 2020 (v1)Journal article
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June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
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July 1, 2020 (v1)Journal article
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June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
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July 1, 2020 (v1)Journal article
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July 1, 2020 (v1)Journal article
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August 20, 2008 (v1)Journal article
Twik-related K+ (TREK) channels produce background currents that regulate cell excitability. In vivo, TREK-1 is involved in neuronal processes including neuroprotection against ischemia, general anesthesia, pain perception, and mood. Recently, we demonstrated that A-kinase anchoring protein AKAP150 binds to a major regulatory domain of TREK-1,...
Uploaded on: December 4, 2022 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: February 22, 2023 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: December 4, 2022 -
September 2001 (v1)Journal article
Two C-terminal splice variants (BI-1 and BI-2, now termed Cav2.1a and Cav2.1b) of the neuronal voltage-gated P/Q-type Ca2+channel a1A pore-forming subunit have been cloned (Mori et al., 1991, Nature, 350, 398±402). BI-1 and BI-2 code for proteins of2273 and 2424 amino acids, respectively, and differ only by their extreme carboxyl-termini...
Uploaded on: December 4, 2022 -
July 10, 2013 (v1)Journal article
CXCR4, a receptor for the chemokine CXCL12 (stromal-cell derived factor-1α), is a G-protein-coupled receptor (GPCR), expressed in the immune and CNS and integrally involved in various neurological disorders. The GABAB receptor is also a GPCR that mediates metabotropic action of the inhibitory neurotransmitter GABA and is located on neurons and...
Uploaded on: October 11, 2023 -
July 10, 2013 (v1)Journal article
CXCR4, a receptor for the chemokine CXCL12 (stromal-cell derived factor-1α), is a G-protein-coupled receptor (GPCR), expressed in the immune and CNS and integrally involved in various neurological disorders. The GABAB receptor is also a GPCR that mediates metabotropic action of the inhibitory neurotransmitter GABA and is located on neurons and...
Uploaded on: December 2, 2022 -
February 5, 2010 (v1)Journal article
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Uploaded on: December 4, 2022