SANTOS VELÁZQUEZ , Ana Isabel De Los

El ciclo celular es un conjunto ordenado de sucesos que conducen a la duplicación celular, y constituye un proceso altamente regulado, en el que la progresión entre las distintas fases que lo constituyen es promovida por la actividad de las proteínas quinasas dependientes de ciclinas (CDKs) y sus subunidades reguladoras, las ciclinas [1, 2]. La...

When chromosomal DNA is damaged, progression through the cell cycle is halted to provide the cells with time to repair the genetic material before it is distributed between the mother and daughter cells. In Saccharomyces cerevisiae, this cell cycle arrest occurs at the G2/M transition. However, it is also necessary to restrain exit from mitosis...

The nucleolus plays a pivotal role in multiple key cellular processes. An illustrative example is the regulation of mitotic exit in Saccharomyces cerevisiae through the nucleolar sequestration of the Cdc14 phosphatase. The peculiar structure of the nucleolus, however, has also its drawbacks. The repetitive nature of the rDNA gives rise to...