SANZ HERRERA , José Antonio

The present Special Issue covers recent advances in the field of tissue engineering applied to bone tissue. Bone tissue engineering is a wide research topic, so di erent works from di erent transversal areas of research are shown. This Special Issue is a good example of a multidisciplinary collaboration in this research field. Authors from di...

This article is concerned with the formulation and implementation of a fast multipole- accelerated BEM for 3-D elastodynamics in the frequency domain, based on the so-called diagonal form for the expansion of the elastodynamic fundamental solu- tion, a multi-level strategy. As usual with the FM-BEM, the linear system of BEM equations is solved...

Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engineering product....

Bone tissue engineering is currently a mature methodology from a research perspective. Moreover, modeling and simulation of involved processes and phenomena in BTE have been proved in a number of papers to be an excellent assessment tool in the stages of design and proof of concept through in-vivo or in-vitro experimentation. In this paper, a...

En este trabajo se presenta una formulación mixta del Método de los Elementos de Contorno (MEC) para el análisis de problemas 3D de Mecánica de la Fractura en materiales piezoeléctricos transversalmente isótropos. La formulación mixta hace uso de la Ecuación Integral de Contorno tanto en Desplazamientos (formulación clásica del método) como en...

A general mixed boundary element formulation for three-dimensional piezoelectric fracture mechanics problems is presented in this paper. The numerical procedure is based on the extended displacement and traction integral equations for external and crack boundaries, respectively. Integrals with strongly singular and hypersingular kernels...

It is established that bone tissue adapts and responds to mechanical loading. Several studies have suggested an existence of positive influence of vibration on the bone mass maintenance. Thus, some bone regeneration therapies are based on vibration of bone tissue under circumstances of disease to stimulate its formation. Frequency of loading...

Background and objectives: Blood vessels form a network of capillaries throughout the body that perform essential functions for life. Vasculogenesis, i.e. the formation of new blood vessels, is regulated by many factors, biochemical ones being among the most important. However, others such as the biomechanical influence on shape, organization...

Self-healing structural materials are recognized as a cost effective and sustainable promising alternative to traditional maintenance methods of civil infrastructures. Great advances are being evidenced both in the synthesis/manufacturing and experimental characterization of these materials. However, there is limited information about reliable...

Magnesium-based biomedical implants offer many advantages versus traditional ones although some challenges are still present. In this context, mathematical modeling and computational simulation may be a useful and complementary tool to evaluate in silico the performance of magnesium biomaterials under different conditions. In this paper, a...

Computational multiscale analyses are currently ubiquitous in science and technology. Different problems of interest-e.g., mechanical, fluid, thermal, or electromagnetic-involving a domain with two or more clearly distinguished spatial or temporal scales, are candidates to be solved by using this technique. Moreover, the predictable capability...

En este trabajo se presenta una formulación del Método de los Elementos de Contorno para resolver problemas de grietas contenidas en solidos anisótropos piezoeléctricos. Se trata de una formulación cl ´ asica (ecuación integral de contorno en ´ desplazamientos) en la que se utiliza la solución fundamental de Deeg. En el frente de grieta se...

Microfluidic capacities for both recreating and monitoring cell cultures have opened the door to the use of Data Science and Machine Learning tools for understanding and simulating tumor evolution under controlled conditions. In this work, we show how these techniques could be applied to study Glioblastoma, the deadliest and most frequent...

Traction force microscopy is a methodology that enables to estimate cellular forces from the measurement of the displacement field of an extracellular matrix (ECM)-mimicking hydrogel that a cell is mechanically interacting with. In this paper, a new inverse and physically-consistent methodology is developed and implemented in the context of 3D...

Data Science has burst into simulation-based engineering sciences with an impressive impulse. However, data are never uncertainty-free and a suitable approach is needed to face data measurement errors and their intrinsic randomness in problems with well-established physical constraints. As in previous works, this problem is here faced by...

Data-driven methods are an innovative model-free approach for engineering and sciences, still in process of maturation. The idea behind is the combination of data analytics techniques, to handle the huge amount of data derived from continuous monitoring or experimental measurements, and of the constraints imposed by universal physical laws,...