SARA TIRENDI

Primary open-angle glaucoma is the second leading cause of irreversible blindness worldwide. Increasing evidence suggests oxidative damage and immune response defects are key factors contributing to glaucoma onset. Indeed, both the failure of the trabecular meshwork tissue in the conventional outflow pathway and the neuroinflammation process,...

Glaucoma is a neurodegenerative disease characterized by vision loss, due to retinal ganglion cell (RGC) death. The RGCs are the first retinal neurons generated during development from multipotent retinal progenitor cells (RPCs), followed by other retinal cells type, i.e. bipolar, horizontal and amacrine cells, Muller glial cells, and cone/rod...

Glaucoma is a multifactorial syndrome in which the development of pro-apoptotic signals are the causes for retinal ganglion cell (RGC) loss. Most of the research progress in the glaucoma field have been based on experimentally inducible glaucoma animal models, which provided results about RGC loss after either the crash of the optic nerve or...

The toxicity of inorganic and organic mixtures (CER 16 05 06*), which derive from analytical laboratory waste, being often unstable, represents a relevant issue for their toxicological interactions. In compliance with the 3Rs policy adopted by the European Commission, a multimodel in vitro approach was set up. Toxicity and the proinflammatory...

Asbestos fibres, including the amphiboles and the serpentine chrysotile (CHR), are classified as carcinogens by the International Agency for Research on Cancer (IARC). Today CHR "safe" mining takes place only in few countries like Russia, China, Africa, and South America, although, to mitigate the health risks associated with CHR, various...

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Asbestos fibres have been considered an environmental hazard for decades. However, little is known about the attempts of circulating immune cells to counteract their toxicity. We addressed the early effects of fibre-released soluble factors (i.e. heavy metals) in naïve immune cells, circulating immediately below the alveolar/endothelial cell...

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