: Eosinophilic esophagitis is a chronic immune-mediated esophageal disease with a Th2 inflammatory response to inhalant and food allergens that cause an eosinophilic infiltration of esophageal mucosa. The diagnosis requires an upper endoscopy with esophageal bioptic samples, in particular the number of eosinophils must be >15 eos/high power...
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2022 (v1)PublicationUploaded on: April 14, 2023
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2017 (v1)Publication
The Lémann Index (LI) was developed to assess the cumulative structural damage of the intestinal tract in patients with Crohn's Disease (CD) independently of clinical and biochemical activity. Recently, the goal of CD focused on obtaining mucosal healing and deep remission rather than simple symptom control. These new therapeutic aims emphasize...
Uploaded on: March 27, 2023 -
2024 (v1)Publication
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Uploaded on: March 16, 2024 -
2016 (v1)Publication
For decades, millions of patients with acid-related disorders have had their acid inhibited effectively and safely first with H2-receptor antagonists (H2RAs) and then with proton pump inhibitors (PPI). As with any pharmacological agent, PPIs have been reported to be associated with some adverse events, but several recent large-scale...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
Purpose of review Rome IV experts have proposed that gastroesophageal reflux disease (GERD) should be diagnosed only in patients with abnormal esophageal acid exposure, and that reflux hypersensitivity (RH) and functional heartburn (FH) both should be considered functional conditions separate from GERD. Although past and recent evidence support...
Uploaded on: February 14, 2024 -
2019 (v1)Publication
Objective: The aim of this study was to assess the safety and efficacy of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet (LFD) in patients with inflammatory bowel disease (IBD). Methods: An LFD is associated with symptom improvement in patients with functional intestinal disorders, although its...
Uploaded on: April 14, 2023 -
2023 (v1)Publication
Introduction: Heartburn is a frequent symptom occurring in daily clinical practice and is mainly associated with gastroesophageal reflux disease (GERD). However, it can be stimulated by various factors and diseases other than GERD can present with heartburn. Therefore, physicians must be very careful in distinguishing GERD from non-GERD...
Uploaded on: January 31, 2024 -
2019 (v1)Publication
Objectives: Up to 40% of inflammatory bowel disease (IBD) patients treated with anti-TNF drugs lose response within 1 year of treatment, therefore requiring drug optimization. Although higher drug trough levels (TLs) are associated with sustained clinical outcomes, there are concerns that they may be associated with a higher risk of adverse...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
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Uploaded on: April 14, 2023 -
2019 (v1)Publication
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Uploaded on: April 14, 2023 -
2016 (v1)Publication
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Uploaded on: April 14, 2023 -
2017 (v1)Publication
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Uploaded on: April 14, 2023 -
2015 (v1)Publication
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Uploaded on: March 27, 2023 -
2020 (v1)Publication
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Uploaded on: April 14, 2023 -
2018 (v1)Publication
Background: The use of therapeutic drug monitoring has been proposed as a useful tool in the management of patients with loss of response to biological therapy in patients with inflammatory bowel disease. Aims: To evaluate whether early, post-induction anti-tumor necrosis factor trough levels and the presence of different types of anti-drug...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
Introduction: Despite the undoubted benefit of proton pump inhibitors (PPIs), they have several shortcomings, such as a slow onset of action and a remarkable inter-individual variability, that limit the complete success of these drugs. Recently, a new PPI, ilaprazole, has been developed and used in GERD patients. Areas covered: The present...
Uploaded on: March 27, 2023