Porous multiphase scaffolds have been proposed in different tissue engineering applications because of their potential to artificially recreate the heterogeneous structure of hierarchically complex tissues. Recently, graded scaffolds have been also realized, offering a continuum at the interface among different phases for an enhanced structural...
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2016 (v1)PublicationUploaded on: April 14, 2023
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2021 (v1)Publication
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Uploaded on: February 7, 2024 -
2020 (v1)Publication
Metastasis is a dynamic process involving the dissemination of circulating tumor cells (CTCs) through blood flow to distant tissues within the body. Nevertheless, the development of an in vitro platform that dissects the crucial steps of metastatic cascade still remains a challenge. We here developed an in vitro model of extravasation composed...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
Simple Summary Immunotherapies are emerging as promising strategies to cure cancer and extend patients' survival. Efforts should be focused, however, on the development of preclinical tools better able to predict the therapeutic benefits in individual patients. In this context, the availability of reliable preclinical models capable of...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
The success of immunotherapeutic approaches strictly depends on the immune cells interaction with cancer cells. While conventional in vitro cell cultures under-represent the complexity and dynamic crosstalk of the tumor microenvironment, animal models do not allow deciphering the anti-tumor activity of the human immune system. Therefore, the...
Uploaded on: October 11, 2023