SCHEIBA , Rafael Manfred

En esta tesis se presenta un análisis estructural de la proteína de unión a ARN HuR y, en particular, se profundiza en el análisis con su estructura modular y a su regulación post-traducional mediante fosforilación. Los resultados obtenidos revelan que los dominios N-terminales RRM1 y RRM2 de HuR funcionan como una unidad, según se deduce de...

Human antigen R (HuR) is a multitasking RNA binding protein involved in posttranscriptional regulation by recognizing adenine- and uracile-rich elements placed at the 3′-untranslated regions of messenger RNAs (mRNAs). The modular architecture of the protein, which consists of two N-terminal RNA recognition motifs (RRMs) in tandem spaced from a...

Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal and central domains (RRM1 and RRM2) are essential for AREs recognition, little is known on the C-terminal RRM3 beyond its implication in HuR oligomerization and apoptotic...