SCHMITT-ULMS , Gerold

Last name: SCHMITT-ULMS

First name: Gerold

August 25, 2009 (v1)

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TMP21 Transmembrane Domain Regulates {gamma}-Secretase Cleavage.

Pardossi-Piquard, Raphaelle Bohm, Christopher Chen, Fusheng

TMP21 has been shown to be associated with the gamma-secretase complex and can specifically regulate gamma-cleavage without affecting epsilon-mediated proteolysis. To explore the basis of this activity, TMP21 modulation of gamma-secretase activity was investigated independent of epsilon-cleavage using an APPepsilon construct which lacks the...

Uploaded on: December 4, 2022
July 16, 2004 (v1)

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The Presenilin Proteins Are Components of Multiple Membrane-bound Complexes That Have Different Biological Activities

Petit-Paitel, Agnès Gu, Yongjun Sanjo, Nobuo

International audience

Uploaded on: December 4, 2022
October 29, 2004 (v1)

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Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes

Petit-Paitel, Agnès Hasegawa, Hiroshi Sanjo, Nobuo

International audience

Uploaded on: December 4, 2022
June 12, 2009 (v1)

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APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.

Pardossi-Piquard, Raphaëlle Yang, Seung-Pil Kanemoto, Soshi

Complexes involved in the gamma/epsilon-secretase-regulated intramembranous proteolysis of substrates such as the amyloid-beta precursor protein are composed primarily of presenilin (PS1 or PS2), nicastrin, anterior pharynx defective-1 (APH1), and PEN2. The presenilin aspartyl residues form the catalytic site, and similar potentially functional...

Uploaded on: December 3, 2022

SCHMITT-ULMS , Gerold

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