BACKGROUND: The prevalence of genetic risk factors has not been systematically evaluated in the setting of complete atriventricular (AV) block complicated by long QT syndrome (LQTS). OBJECTIVE: This study was performed to determine to what extent acquired LQTS in the context of AV block has a genetic substrate. METHODS: Among 420 recipients of...
-
February 2007 (v1)Journal articleUploaded on: February 28, 2023
-
February 13, 2023 (v1)Journal articleA need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1
hERG, the pore-forming subunit of the rapid component of the delayed rectifier K + current, plays a key role in ventricular repolarization. Mutations in the KCNH2 gene encoding hERG are associated with several cardiac rhythmic disorders, mainly the Long QT syndrome (LQTS) characterized by prolonged ventricular repolarization, leading to...
Uploaded on: October 13, 2023