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SCHULERT , Grant

Last name: SCHULERT

First name: Grant

2017 (v1)

Publication

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Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

Bracaglia, Claudia de Graaf, Kathy Pires Marafon, Denise

Objectives Interferon-gamma (IFN gamma) is the pivotal mediator in murine models of primary haemophagocytic lymphohistiocytosis (pHLH). Given the similarities between primary and secondary HLH (sec-HLH), including macrophage activation syndrome (MAS), we investigate the involvement of the IFN gamma pathway in MAS by evaluating levels of IFN...

Uploaded on: March 27, 2023
2018 (v1)

Publication

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In silico validation of the autoinflammatory disease damage index

Ter Haar, Nienke M. Van Delft, Amber Laetitia Justine Annink, Kim Valerie

Introduction Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour...

Uploaded on: April 14, 2023