SCOGNAMIGLIO V.

In chrysotile, the most commercialized asbestos, Fe and other toxic metals are worth considering in its pathogenicity (Gualtieri et al., 2019); in fact, large amounts of Fe (>1000 ppm) and trace metals (Cr, Ni, Co, Mn, ...) are also intimately associated with the raw material. Since both Fe and trace metals are usually isomorphous substituent...

In chrysotile, the most commercialized asbestos species, Fe and other metals are worth considering in its potential toxicity (Gualtieri et al., 2019); in fact, large amounts of Fe (>1000 ppm) and trace metals (Cr, Ni, Co, Mn, etc.) are also intimately associated with the raw material. Since both Fe and trace metals are usually isomorphous...

Inhalation of mineral fibres is associated with the onset of an inflammatory activity in the lungs and the pleura responsible for the development of fatal malignancies. It is known that cell damage is a necessary step for triggering the inflammatory response. However, the mechanisms by which mineral fibres exert cytotoxic activity are not fully...

Today, despite considerable efforts undertaken by the scientific community, the mechanisms of carcinogenesis of mineral fibres remain poorly understood. A crucial role in disclosing the mechanisms of action of mineral fibres is played by in vitro and in vivo models. Such models require experimental design based on negative and positive...