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SCOTI , Beatrice

Last name: SCOTI

First name: Beatrice

2018 (v1)

Publication

Metadata-only

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

Thellung, Stefano Scoti, Beatrice Corsaro, Alessandro

According to the "gain-of-toxicity mechanism", neuronal loss during cerebral proteinopathies is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins, although it is still debated which aggregation state actually corresponds to the neurotoxic entity. Autophagy, originally described as a variant of programmed cell...

Uploaded on: March 27, 2023