SEGUIN , Laetitia

International audience

Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung...

Abstract Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the...

Senescent cells accumulate in aging tissues, and their elimination can favor healthy aging 1-4 . Therefore, therapeutic interventions targeting cellular senescence may be promising strategies for delaying or reversing a vast range of age-related diseases 5 . As cells of the immune system are responsible for senescent cell elimination 6-11 , a...

While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles,we identify a unique subpopulation based on addiction to the high-affinity glucose transporter, Glut3.Although Glut3 is a known driver of a cancer stem cell phenotype, direct targeting is complicated by itsexpression in neurons. Using...