SERMET-GAUDELUS , Isabelle

Young cystic fibrosis (CF) patients' airways are mainly colonized by Staphylococcus aureus, while Pseudomonas aeruginosa predominates in adults. However, the mechanisms behind this infection switch are unclear. Here, we show that levels of type-IIA-secreted phospholipase A2 (sPLA2-IIA, a host enzyme with bactericidal activity) increase in...

Diffuse bronchiectasis is a common problemin respiratory clinics. We hypothesized that mutations inthe solute carrier 26A9 (SLC26A9) gene, encoding for achloride (Cl−) transporter mainly expressed in lungs, maylead to defects in mucociliary clearance. We describe twomissense variants in theSLC26A9gene in heterozygotepatients presenting with...