Objetivos: comparar el efecto de la administración de una lágrima artificial ( XilinFresh o VisuXL ) en dos grupos d e pacientes menopáusicas sometidas a algún tratamiento farmacológico que contribuya a que se produzca sequed ad ocular. Material y métodos: se evaluó la sintomatología relacionada con la sequedad ocular, la ...
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January 20, 2020 (v1)PublicationUploaded on: March 27, 2023
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July 26, 2018 (v1)Publication
Capítulos embargados: resultados, discusión y conclusiones.
Uploaded on: March 27, 2023 -
November 30, 2023 (v1)Publication
Reelin is an extracellular matrix protein that plays a critical role in neuronal migration. Here we show that the mucosa of human colon expresses reelin, its receptors ApoER2 and VLDLR, and its effector protein Dab1. Immunohistochemical analyses reveal that reelin expression is restricted to pericryptal myofibroblasts; Dab1 is detected at...
Uploaded on: December 3, 2023 -
November 16, 2023 (v1)Publication
The expression of the phosphoinositides phosphatases Synaptojanins (Synjs) 1 and 2 has been shown in brain and in some peripheral tissues, but their expression in the intestine has not been reported. Herein we show that the small and large intestine express Synj1 and Synj2. Their mRNA levels, measured by RT-PCR, are not affected by development...
Uploaded on: November 25, 2023 -
December 11, 2023 (v1)Publication
La reelina puede ser utilizada como un único biomarcador en el diagnóstico e identificación de diferentes patologías intestinales y como biomarcador de la transición desde una enfermedad inflamatoria intestinal hasta tumorogénesis. Los inventores han demostrado que, en respuesta a un daño tisular, como la inflamación, el intestino...
Uploaded on: December 13, 2023 -
November 11, 2022 (v1)Publication
Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions to colon cancer and tried to elucidate reelin regulation under these transition processes. Samples of healthy and pathological...
Uploaded on: March 24, 2023 -
April 8, 2019 (v1)Publication
We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis. The aim of the current study was to determine whether reelin protects from colorectal cancer and how reelin defends from colon pathology. In the colon of...
Uploaded on: December 4, 2022