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SERVEL , Nathalie

Last name: SERVEL

First name: Nathalie

2018 (v1)

Publication

Metadata-only

The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism

Pesce, Emanuela Sondo, Elvira Ferrera, Loretta

The mutation F508del, responsible for a majority of cystic fibrosis cases, provokes the instability and misfolding of the CFTR chloride channel. Pharmacological recovery of F508del-CFTR may be obtained with small molecules called correctors. However, treatment with a single corrector in vivo and in vitro only leads to a partial rescue, a...

Uploaded on: April 14, 2023