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SHAHBAZIAN , Anaid

Last name: SHAHBAZIAN

First name: Anaid

May 23, 2007 (v1)

Journal article

Metadata-only

Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis.

Wultsch, Thomas Painsipp, Evelin Shahbazian, Anaid

Gastric acid challenge of the rat and mouse stomach is signalled to the brainstem as revealed by expression of c-Fos. The molecular sensors relevant to the detection of gastric mucosal acidosis are not known. Since the acid-sensing ion channels ASIC2 and ASIC3 are expressed by primary afferent neurons, we examined whether knockout of the ASIC2...

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