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SIBILLE , Brigitte

Last name: SIBILLE

First name: Brigitte

Email: Brigitte.SIBILLE@univ-cotedazur.fr

Institution: UCA

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March 17, 2021 (v1)

Journal article

Metadata-only

Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity

Rousseau, Anne-Sophie Murdaca, Joseph Le Menn, Gwenaëlle

Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4+ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle (SKM) regeneration and mass maintenance. In this...

Uploaded on: December 4, 2022
February 2019 (v1)

Journal article

Metadata-only

Decrease in αβ/γδ T-cell ratio is accompanied by a reduction in high-fat diet-induced weight gain, insulin resistance, and inflammation

Le Menn, Gwenaëlle Sibille, Brigitte Murdaca, Joseph

The implication of αβ and γδ T cells in obesity-associated inflammation and insulin resistance (IR) remains uncertain. Mice lacking γδ T cells show either no difference or a decrease in high-fat diet (HFD)-induced IR, whereas partial depletion in γδ T cells does not protect from HFD-induced IR. αβ T-cell deficiency leads to a decrease in white...

Uploaded on: December 4, 2022