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SICILIANO , Massimo

Last name: SICILIANO

First name: Massimo

2015 (v1)

Publication

Metadata-only

Hepatitis C virus RNA levels at week-2 of telaprevir/boceprevir administration are predictive of virological outcome

Cento, Valeria Di Paolo, Daniele Di Carlo, Domenico

Background: Triple therapy with telaprevir/boceprevir + pegylated-interferon + ribavirin can achieve excellent antiviral efficacy, but it can be burdened with resistance development at failure. Aims: To evaluate kinetics of hepatitis C virus (HCV) RNA decay and early resistance development, in order to promptly identify patients at highest risk...

Uploaded on: April 14, 2023
2017 (v1)

Publication

Metadata-only

Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens

Cento, Valeria Nguyen, Thi Huyen Tram Di Carlo, Domenico

Background: Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinations to evaluate their mode of action and...

Uploaded on: April 14, 2023