SIMEON V.

Background: Candidaemia remains associated with high mortality and increased costs worldwide. Objective: To assess the changes over time in the relative prevalence of non-albicans candidaemia (NAC). Methods: A systematic review, meta-analysis and meta-regression were performed. Observational studies investigating the epidemiology of...

Aim: The aim of the study is to analyse whether letrozole (L) and zoledronic acid plus L (ZL) are more effective than tamoxifen (T) as adjuvant endocrine treatment of premenopausal patients with breast cancer with hormone receptor–positive (HR+) tumours. Patients and methods: In a phase 3 trial, 1065 premenopausal patients with HR + early...