S

SIMMS L. A.

Last name: SIMMS L. A.

2020 (v1)

Publication

Metadata-only

Overlapping genetic architecture between Parkinson disease and melanoma

Dube U. Ibanez L. Budde J. P.

Epidemiologic studies have reported inconsistent results regarding an association between Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic architecture between these diseases can support epidemiologic findings and identify common risk genes and biological pathways. Here, we apply polygenic, linkage...

Uploaded on: April 14, 2023
2020 (v1)

Publication

Metadata-only

Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Landi M. T. Bishop D. T. MacGregor S.

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10−8) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical...

Uploaded on: April 14, 2023