SIVERA , Raphaël

In medical imaging, the statistical analysis of deformations enables the characterization of the effects of neurodegenerative diseases on the brain morphology. Deformations are able to capture precise changes but their analysis raises specific methodological challenges and the results may be difficult to interpret. The objective of this thesis...

In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a generative model. A reference morphology is deformed along specific trajectories to match subject specific...

Objective: The Multidomain Alzheimer Preventive Trial (MAPT) was designed to assess the effect of omega-3 supplementation and a multidomain intervention (physical activity, cognitive training and nutritional advice) on cognitive decline of people with subjective memory complaint. In term of cognitive testing, no significant effect on cognitive...