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G

SMITH , Gregory A.

Last name: SMITH

First name: Gregory A.

2018 (v1)

Publication

Metadata-only

Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection

Zimmer, Bastian Ewaleifoh, Osefame Harschnitz, Oliver

Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western countries. Some HSE children carry inborn errors of the Toll-like receptor 3 (TLR3)-dependent IFN-α/β– and -λ–inducing pathway. Induced pluripotent stem cell (iPSC)-derived cortical neurons with TLR3 pathway mutations are highly...

Uploaded on: April 14, 2023