SMOLEN , Prune

The basement membrane (BM) is a specialized extracellular matrix that provides mechanical and physical support to the organs it surrounds. During development, tissues, under the control of morphogens, grow and change shape. Thus, the BM that surrounds them must adapt to these changes, which implies a modulation of its biogenesis. However, the...

International audience

All epithelia are surrounded by a specialized extracellular matrix, the basement membrane (BM). During development, this BM contributes to the morphogenesis of epithelial organs through different functions, the most recently added one being the shaping of the tissue. Seminal studies highlight the importance of the mechanical properties of the...