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2014 (v1)PublicationUploaded on: April 14, 2023
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2014 (v1)Publication
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Uploaded on: April 14, 2023 -
2019 (v1)Publication
Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+ known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels. How NMN is taken up into cells has not been entirely clear. Here we show that the Slc12a8 gene encodes a specific NMN transporter. We find that...
Uploaded on: April 14, 2023 -
2017 (v1)Publication
The NAD+-dependent deacetylase SIRT6 is an emerging cancer drug target, whose inhibition sensitizes cancer cells to chemo-radiotherapy and has pro-differentiating effects. Here we report on the identification of novel SIRT6 inhibitors with a salicylate-based structure. The new SIRT6 inhibitors show improved potency and specificity compared to...
Uploaded on: April 14, 2023