2023 (v1)
Publication
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Uploaded on: February 14, 2024
S
D
SONCINI , Debora
Last name: SONCINI
First name: Debora
Email: debora.soncini@unige.it
Institution: UNIGE
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2023 (v1)Publication
: Sirtuin 6 (SIRT6) is a member of the mammalian NAD+-dependent deac(et)ylase sirtuin family. SIRT6's anti-inflammatory roles are emerging increasingly often in different diseases and cell types, including endothelial cells. In this study, the role of SIRT6 in pro-inflammatory conditions was investigated by engineering human umbilical vein...
Uploaded on: February 11, 2024 -
2017 (v1)Publication
The NAD+-dependent deacetylase SIRT6 is an emerging cancer drug target, whose inhibition sensitizes cancer cells to chemo-radiotherapy and has pro-differentiating effects. Here we report on the identification of novel SIRT6 inhibitors with a salicylate-based structure. The new SIRT6 inhibitors show improved potency and specificity compared to...
Uploaded on: April 14, 2023