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SOUBEYRAN , Isabelle

Last name: SOUBEYRAN

First name: Isabelle

January 5, 2010 (v1)

Journal article

Metadata-only

KRAS and BRAF Mutational Status in Primary Colorectal Tumors and Related Metastatic Sites: Biological and Clinical Implications.

Italiano, Antoine Hostein, Isabelle Soubeyran, Isabelle

BACKGROUND: KRAS and BRAF mutations in primary colorectal tumors (PT) are predictive of nonresponse to anti-epidermal growth factor receptor (EGFR) antibodies in patients with metastatic colorectal cancer (mCRC). The question of primary resistance to anti-EGFR treatment as a result of the presence of KRAS or BRAF mutations only in metastases...

Uploaded on: December 3, 2022