SOUSSIA , Ismail Ben

TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli,including bioactive lipids, mechanical stretch and temperature, into electrical signals.The nature of the structural changes that regulate their activity remains an openquestion. Here, we show that a cytoplasmic domain (the proximal C-ter domain, pCt)exerts...

TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli,including bioactive lipids, mechanical stretch and temperature, into electrical signals.The nature of the structural changes that regulate their activity remains an openquestion. Here, we show that a cytoplasmic domain (the proximal C-ter domain, pCt)exerts...

International audience

The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we report the synthesis of a series of substituted acrylic acids (1-54) based on our previous work with caffeate...