SPAGGIARI , Grazia Maria

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MicroRNAs are involved in the regulation of different functions in immune and non-immune cells. Here we show that miR-24-3p functionally interacts with FASLG mRNA and down-regulates its expression. This interaction occurs in human natural killer cells (NK), leading to the modulation of FasL surface expression. Moreover, miR-24-3p also modulates...

Simple Summary Different components of the tumor microenvironment, such as cancer-associated fibroblasts and tumoral mesenchymal stromal cells, play a major role in cancer progression, metastatic spread and resistance to chemo-immunotherapy. Neuroblastoma tumor-associated mesenchymal stromal cells (NB-TA-MSC) have been extensively characterized...