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Last name: STEPHAN
First name: Delphine
International audience
We previously discovered the implication of membrane-type 5-matrix metalloproteinase (MT5-MMP) in Alzheimer's disease AD pathogenesis. Here we shed new light on pathogenic mechanisms by which MT5-MMP controls APP processing and the fate of amyloid beta peptide (Aβ), its precursor C99 and C83. We found in HEK carrying the APP Swedish familial...
Abbreviations: 3xTG, transgenic mice expressing human APP, MAPT, and PSEN1 genes with three familial mutations; 5xFAD, transgenic mice expressing human APP and PSEN1 genes with five familial mutations; AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, amyloid protein precursor; Aβ, beta-amyloid peptide; BACE-1, beta-site...
We previously reported that deficiency of membrane-type five matrix metalloproteinase (MT5-MMP) prevents amyloid pathology in the cortex and hippocampus of 5xFAD mice, and ameliorates the functional outcome. We have now investigated whether the integrity of another important area affected in Alzheimer's disease (AD), the frontal cortex, was...