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SYED , Nelofer

Last name: SYED

First name: Nelofer

November 7, 2022 (v1)

Publication

Metadata-only

The bitter side of epigenetics: variability and resistance to chemotherapy

Hajji, Nabil García-Domínguez, Daniel J. Hontecillas-Prieto, Lourdes

One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing number of clinical trial failures appears to be the paucity of accurate, reproducible and robust drug resistance testing methods. Most research assessing the resistance of cancers to chemotherapy has concentrated on...

Uploaded on: December 2, 2022
June 8, 2022 (v1)

Publication

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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors

Hajji, Nabil García Revilla, Juan Sarmiento Soto, Manuel

New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20 in a non-arginine-auxotrophic cellular background (argininosuccinate synthetase 1 positive)....

Uploaded on: December 4, 2022