1997 (v1)
Publication
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Uploaded on: April 14, 2023
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2007 (v1)Publication
The conversion of the prion protein (PrP) into a protease-resistant isoform (Prp(Res)) is considered the pathogenic event responsible for prion encephalopathies. Microglia activation accompanies PrPRes deposition representing an early event in the progression of these diseases. It is now believed that microglial cells play a worsening, if not...
Uploaded on: March 25, 2023 -
2007 (v1)Publication
The mayor pathologic hallmarks of Alzheimer's disease (AD) are senile plaque and neurofibrillary tangles. Senile plaque are primarily made up of deposits of amyloid-beta protein, a proteolytic product derived from the amyloid precursor protein (APP). APP is a transmembrane protein detected into the endoplasmic reticulum, in the Golgi apparatus,...
Uploaded on: May 13, 2023