TIRENDI , Sara

Glaucoma is a progressive optic neuropathy that leads to irreversible blindness. The TM plays a pivotal role in conventional aqueous humor outflow pathways. The progressive morphological and functional decline of the TM leads to increased intraocular pressure (IOP), a hallmark of this disease. Many other conditions contribute to the development...

Glaucoma is a progressive optic neuropathy that leads to irreversible blindness. From a molecular point of view it is possible to define glaucoma as a syndrome that develops pro-apoptotic signals towards the optic nerve head. In the pathogenesis of glaucoma a central role is played by the trabecular meshwork (TM) that, together with the...

. In vitro animal models of the nervous system have been in use for many years provide an important tool for functional studies at cellular and molecular levels. Aim of our study was to generate standardized neural precursor populations from human Adipose-derived Stem Cells (hADSC), by tissue, routinely discarded after liposuction surgeries....

On September 29-30, 2016, the 8th edition of the training course on "Alternative Approach to Animal Testing and Cell Cultures, According to European Laws", was held in Genoa, chaired by Prof. Anna Maria Bassi and organized and hosted by the team of Laboratory Analysis and Research in Physiopathology (LARF), Department of Experimental ...

A physiologically relevant in vitro human-based model could be the 'gold standard' to clarify the pathological steps involved in glaucoma onset. In this regard, human 3D cultures may represent an excellent starting point to achieve this goal. Indeed, the 3D matrix allows to re-create the in vivo-like tissue architecture, maintaining its...

The oxidation therapy, an unique antitumor strategy, is based on delivering excess oxidative stress or disrupting the antioxidative defense systems into tumor cells. Lipid-hydroperoxides (LOOHs) derived from polyunsaturated fatty acids, are stable intermediates of oxidative process, and at non-toxic concentrations can act as signalling...