TAGUA JÁÑEZ , Antonio Jesús

Tissue morphogenesis is intimately linked with the complex changes that occur in the shape and organization of individual cells. In curved epithelia, cells possess the capacity to intercalate along their own apico-basal axes adopting a distinct shape named "scutoid". This conformation facilitates the minimization of energy within the...

Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond the traditional polygon distribution analysis, capturing other organizational traits that improve the characterization of...

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Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function of whole tissues. Combining 3D epithelial imaging with advanced deep-learning segmentation methods is essential for enabling...