TARANCON DIEZ , Laura

La presente Tesis Doctoral se ha centrado en estudiar uno de los principales problemas clínicos de los pacientes infectados por VIH bajo tratamiento antirretroviral combinado (TARc), que es la prevalencia y morbi-mortalidad de procesos no definitorios de SIDA, entre los que se incluyen las enfermedades cardiovasculares. En un diseño...

The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule. Within human CD4+ T lymphocytes from healthy donors, the inhibitory receptor CD300a is differentially expressed among different T helper subsets. However, there...

Approximately 25% of elite controllers (ECs) lose their virological control by mechanisms that are only partially known. Recently, immunovirological and proteomic factors have been associated to the loss of spontaneous control. Our aim was to perform a metabolomic approach to identify the underlying mechanistic pathways and potential biomarkers...