TAYARA , Khadija

La metformina es un fármaco antidiabético oral ampliamente utilizado con propiedades antiinflamatorias conocidas debido a su acción sobre la AMP cinasa. Esta droga ha mostrado un efecto protector en varios tejidos del cerebro, incluidas las neuronas corticales. Sin embargo, el efecto de la metformina sobre la sustancia negra (SN), la principal...

Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the inflammatory response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase...

The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN), the main structure affected in Parkinson's disease (PD), has not yet been studied in depth....