TEJEDO HUAMÁN , Juan Rigoberto

En los últimos años se han acumulado evidencias concernientes al papel de la apoptosis en el control de la población de células beta en la patogénesis de la IDDM. Así se ha visto que la apoptosis en células beta de roedores está mediada por la generación de óxido nítrico (NO) en un proceso regulado por citoquinas inflamatorias. Sin embargo...

β-cells release hexameric Zn2+-insulin into the extracellular space, but monomeric Zn2+-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, but they seem to be Zn2+ concentration-dependent. In this study, we investigate the influence of albumin binding to Zn2+ on...

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Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. Though the gene regulatory mechanism for pluripotency has been investigated in recent years, it is still not completely understood. Here, we show several signaling pathways involved in the maintenance of pluripotency. To...