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TESSITORE , Sara

Last name: TESSITORE

First name: Sara

2023 (v1)

Publication

Metadata-only

Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

Torazza, Carola Provenzano, Francesca Gallia, Elena

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage. Glutamate (Glu)-mediated excitotoxicity and group I metabotropic glutamate receptors (mGluRs) play a pathological role in the disease...

Uploaded on: February 14, 2024