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A

THÉVENET , Aurélie

Last name: THÉVENET

First name: Aurélie

January 1, 2012 (v1)

Journal article

Metadata-only

Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.

Flammang, Brice Pardossi-Piquard, Raphaëlle Sevalle, Jean

One of the major pathological hallmarks of brains affected with Alzheimer's disease (AD) is the senile plaque, an extracellular deposit mainly composed of a set of highly insoluble peptides of various lengths (39-43 amino acids) referred to as amyloid-β (Aβ) peptides. Aβ peptides are derived from combined proteolytic cleavages undergone on the...

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