Schizophrenia is a chronic mental illness affecting 0.4% of the population. Existing antipsychotic drugs are mainly used to treat positive symptoms such as hallucinations but have only poor effects on negative symptoms such as cognitive deficits or depression. TREK and TRAAK channels are two P domain background potassium channels activated by...
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March 2, 2007 (v1)Journal articleUploaded on: February 28, 2023
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June 3, 2021 (v1)Publication
International audience
Uploaded on: December 4, 2022 -
February 6, 2022 (v1)Conference paper
One of the major diagnostic criteria for Autism Spectrum Disorder (ASD) is the recognition of stereotyped behaviors. However, it primarily relies on parental interviews and clinical observations, which result in a prolonged diagnosis cycle preventing ASD children from timely treatment. To help clinicians speed up the diagnosis process, we...
Uploaded on: December 3, 2022 -
June 2021 (v1)Journal article
Childhood-Onset Schizophrenia (COS) is a very rare and severe psychiatric disorder defined by adult schizophrenia symptoms occurring before the age of 13. We report a microduplication in the 10q26.3 region including part of the Inositol Polyphosphate-5-Phosphatase A (INPP5A) gene that segregates with Schizophrenia Spectrum Disorders (SSDs) in...
Uploaded on: December 3, 2022 -
June 7, 2018 (v1)Journal article
In the actual context of terrorism targeting children and families, it seems essential to describe different experiences of pediatric psychological emergency devices after such unexpected mass trauma. Here we testify our experience of the psychological emergency care setup dedicated to children and families during the first 48 hours after the...
Uploaded on: December 4, 2022 -
August 20, 2008 (v1)Journal article
Twik-related K+ (TREK) channels produce background currents that regulate cell excitability. In vivo, TREK-1 is involved in neuronal processes including neuroprotection against ischemia, general anesthesia, pain perception, and mood. Recently, we demonstrated that A-kinase anchoring protein AKAP150 binds to a major regulatory domain of TREK-1,...
Uploaded on: December 4, 2022 -
December 18, 2019 (v1)Journal article
Childhood-onset schizophrenia (COS), a very rare and severe chronic psychiatric condition, is defined by an onset of positive symptoms (delusions, hallucinations and disorganized speech or behavior) before the age of 13. COS is associated with other neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit and...
Uploaded on: December 4, 2022 -
2016 (v1)Journal article
Introduction: In France, over recent years, the prescription rate of antipsychotic (AP) remained stable in children and adolescents. Prescription of second-generation antipsychotics increased, whereas prescription of first-generation antipsychotics decreased. Off-label prescriptions are very frequent in this population. Adverse events (AEs) in...
Uploaded on: February 28, 2023 -
April 2024 (v1)Journal article
International audience
Uploaded on: July 27, 2024 -
December 13, 2006 (v1)Journal article
TREK channels are unique among two-pore-domain K(+) channels. They are activated by polyunsaturated fatty acids (PUFAs) including arachidonic acid (AA), phospholipids, mechanical stretch and intracellular acidification. They are inhibited by neurotransmitters and hormones. TREK-1 knockout mice have impaired PUFA-mediated neuroprotection to...
Uploaded on: December 4, 2022 -
December 11, 2023 (v1)Conference paper
StressID is a new dataset specifically designed for stress identification from unimodal and multimodal data. It contains videos of facial expressions, audio recordings, and physiological signals. The video and audio recordings are acquired using an RGB camera with an integrated microphone. The physiological data is composed of...
Uploaded on: November 25, 2023 -
September 12, 2018 (v1)Journal article
Background Gender distribution varies across neurodegenerative disorders, with, traditionally, a higher female frequency reported in Alzheimer's disease (AD) and a higher male frequency in Parkinson's disease (PD). Conflicting results on gender distribution are reported concerning dementia with Lewy bodies (DLB), usually considered as an...
Uploaded on: December 3, 2022 -
January 21, 2022 (v1)Journal article
Workshops using arts and board games are forms of non-pharmacological intervention widely employed in seniors with neurocognitive disorders. However, clear guidelines on how to conduct these workshops are missing. The objective of the Art and Game project (AGAP) was to draft recommendations on the structure and content of workshops for elderly...
Uploaded on: December 3, 2022 -
2017 (v1)Journal article
The use of Serious Games (SG) in the health domain is expanding. In the field of neurodegenerative disorders (ND) such as Alzheimer's disease, SG are currently employed both to support and improve the assessment of different functional and cognitive abilities, and to provide alternative solutions for patients'...
Uploaded on: December 4, 2022