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2018 (v1)PublicationUploaded on: April 14, 2023
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2021 (v1)Publication
Cardiac amyloidosis (CA) is an increasingly recognized myocardial infiltrative disease, causing pseudo-hypertrophy of the heart, diastolic dysfunction and heart failure. Growing efforts are ongoing to optimize screening and diagnostic algorithms for CA [1]. This is motivated by the surfacing of targeted therapies, which are supposed to be more...
Uploaded on: March 27, 2023 -
2019 (v1)Publication
Tyr78Phe is a rare pathogenic transthyretin (TTR) mutation. Few previous reports described a late-onset hereditary transthyretin-related amyloidosis (ATTR-m) form with a variable phenotype, mainly dominated by neurological manifestations. We describe the case of a 69-year-old male with massive but asymptomatic cardiac infiltration and only...
Uploaded on: April 14, 2023 -
2018 (v1)Publication
Background: Valve-in-valve transcatheter aortic valve implantation for degenerated aortic bioprostheses is an effective option for patients at high risk for redo surgery, even if it may be burdened by complications more common in specific settings, such as, coronary artery obstruction. Case presentation: We present the case of a Caucasic...
Uploaded on: April 14, 2023 -
2018 (v1)Publication
Objective: Rare disease Background: Spontaneous coronary artery dissection is the most common etiology of pregnancy-associated myocardial infarction. It is characterized by high rates of maternal morbidity and mortality and may cause fetal complications and death as well. Case Report: A 44-year-old female (G2P1) suffered from pregnancy-related...
Uploaded on: April 14, 2023 -
2021 (v1)Publication
The intracellular tyrosine kinase inhibitor nintedanib has shown great efficacy for the treatment of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. However, the incidence rate of myocardial infarction (MI) among participants in landmark IPF trials was remarkable, peaking at 3/100 patient-years. Although subjects with...
Uploaded on: February 14, 2024 -
2020 (v1)Publication
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Uploaded on: April 14, 2023 -
2019 (v1)Publication
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Uploaded on: April 14, 2023 -
2022 (v1)Publication
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Uploaded on: January 31, 2024 -
2021 (v1)Publication
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Uploaded on: April 14, 2023 -
2018 (v1)Publication
In hypertrophic cardiomyopathy (HC), a process of left ventricular (LV) remodeling carrying an adverse prognosis has been described. Conversely, a gradual and benign LV wall thinning has been suggested but never investigated. Therefore, we studied a HC cohort over a long period of time to evaluate the occurrence of a LV remodeling with a benign...
Uploaded on: April 14, 2023 -
2023 (v1)Publication
Cardiomyopathies are disease of the cardiac muscle largely due to genetic alterations of proteins with 'structural' or 'functional' roles within the cardiomyocyte, going from the regulation of contraction-relaxation, metabolic and energetic processes to ionic fluxes. Modifications occurring to these proteins are responsible, in the vast...
Uploaded on: February 11, 2024 -
2023 (v1)Publication
Backgorund: Hereditary transthyretin(vATTR) cardiac amyloidosis has extremely different features according to the type of transthyretin(TTR) mutation. Data about electrocardiographic findings(ECG) in vATTR are limited and not informative of genotype correlation. Aim of this study is to analyze ECG characteristics and their correlation to...
Uploaded on: February 11, 2024 -
2022 (v1)Publication
Aims The incidence and risk factors of pacemaker (PM) implantation in patients with cardiac amyloidosis (CA) are largely unexplored. We sought to characterize the trends in the incidence of permanent PM and to identify baseline predictors of future PM implantation in light-chain (AL) and transthyretin (ATTR) CA. Methods and results Consecutive...
Uploaded on: February 11, 2024 -
2023 (v1)Publication
Background: Data on the incidence and factors associated with de novo atrial fibrillation (AF) in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is limited. We described the incidence and factors associated with de novo AF in patients diagnosed with ATTRwt-CA to drive tailored arrhythmia screening.Methods: Multicenter,...
Uploaded on: February 11, 2024 -
2022 (v1)Publication
Background: Low QRS voltages (LQRSVs) are a common electrocardiographic feature in patients with light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) cardiac amyloidosis (CA). Objectives: The aim of this study was to identify clinical and echocardiographic correlates of LQRSV and to investigate their prognostic significance in...
Uploaded on: February 11, 2024