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TKACHENKO , Kateryna

Last name: TKACHENKO

First name: Kateryna

2024 (v1)

Publication

Metadata-only

A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells

Iervasi, Erika Coronel Vargas, Gabriela Bachetti, Tiziana

Cutaneous melanoma is the most dangerous and deadly form of human skin malignancy. Despite its rarity, it accounts for a staggering 80% of deaths attributed to cutaneous cancers overall. Moreover, its final stages often exhibit resistance to drug treatments, resulting in unfavorable outcomes. Hence, ensuring access to novel and improved...

Uploaded on: September 7, 2024
2023 (v1)

Publication

Metadata-only

Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology

Ben Toumia, Iméne Bachetti, Tiziana Chekir-Ghedira, Leila

: Background and purpose: Lung cancer is the leading cause of death in both men and women, constituting a major public health problem worldwide. Non-small-cell lung cancer accounts for 85%-90% of all lung cancers. We propose a compound that successfully fights tumor growth in vivo by targeting the enzyme GARS1. Experimental approach: We present...

Uploaded on: February 13, 2024