TOMA M.

Purpose of Review: To present the randomized controlled trial (RCT) evidence and highlight the areas of uncertainty regarding direct oral anticoagulants (DOAC) for cancer-associated venous thromboembolism (CAT). Recent Findings: In the last years, four RCTs have shown that rivaroxaban, edoxaban, and apixaban are at least as effective as...

Immune-checkpoint inhibitors (ICIs) represent a successful paradigm in the treatment of cancer. ICIs elicit an immune response directed against cancer cells, by targeting the so-called immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus. Such response, however,...

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Compared to their fossil counterparts, living brachiopods are investigated far less often, due to their occurrence in remote environments such as dark caves or deep environments. Due to the scarcity of studies targeting in situ brachiopods' populations, large-scale information on their distribution and ecological preferences is still lacking,...

Antipatharians (black corals) are major components of mesophotic ecosystems in the Mediterranean Sea. The arborescent species Antipathella subpinnata has received particular attention as it is the most abundant and forms dense forests harbouring high levels of biodiversity. This species is currently categorized as "Near Threatened" in the IUCN...

The precious coral Corallium rubrum (Linnaeus, 1758) is a charismatic Mediterranean species. A recent large-scale investigation along the Italian coast highlighted its widespread occurrence at mesophotic and upper bathyal depths, especially on coralligenous and bathyal vertical hardgrounds. The lack of morphometric data limited the...

The sea star Hymenodiscus coronata is the only Mediterranean representative of the deepsea order Brisingida. In the North-eastern Atlantic Ocean, this species is known to create dense aggregations, while, in the Mediterranean basin, it is generally reported as scattered individuals. Through the analysis of the video footage obtained from an...

Differently from the North Atlantic Ocean, only few examples of sponge grounds are known from the Mediterranean Sea, mainly thriving in the deep sea. In this study, a novel temperate mesophotic ecosystem dominated by massive keratose sponges is reported from the Ligurian deep continental shelf. An extensive Remotely Operated Vehicle (ROV)...

1. Detailed knowledge about the distribution of species in need of protection is required for the management of Marine Protected Areas, a major tool to reduce marine biodiversity loss. Such knowledge is deficient for most marine invertebrates. 2. Axinella polypoides is a marine sponge included on the list of protected species by the Barcelona...

Aims: We systematically reviewed the European real-world evidence (RWE) about sacubitril-valsartan for heart failure with reduced ejection fraction. Methods and results: Twenty-one articles, including 16 952 subjects, were identified until 31 October 2020. Taking as reference the PARADIGM-HF cohort, few baseline characteristics were presented...

The ongoing prospective, single-arm, observational, phase 4 ETNA-AF Europe study is collecting real-world data about the safety and, secondarily, the effectiveness and therapeutic adherence of newly prescribed edoxaban for non-valvular atrial fibrillation in Europe.

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