TORAZZA CAROLA

Last name: TORAZZA CAROLA

2022 (v1)

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The negative allosteric modulator CTEP ameliorates the reactive phenotype of iastrocytes from patients affected by Amyotrophic Lateral Sclerosis

Tessitore Sara Torazza Carola Kumar Mandeep

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Uploaded on: July 3, 2024
2024 (v1)

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Genetic and pharmacological effects by blocking mGlu5 receptor in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Bacchetti Francesca Bonifacino Tiziana Torazza Carola

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Uploaded on: July 3, 2024
2022 (v1)

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The negative allosteric modulator CTEP ameliorates the reactive phenotype of human-derived iAstrocytes differentiated from iNPCs of patients affected by Amyotrophic Lateral Sclerosis

Tessitore Sara Torazza Carola Kumar Mandeep

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Uploaded on: July 3, 2024
2024 (v1)

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Preclinical study showing a gender specific protective properties of conjugated linoleic acid (CLA) for amyotrophic lateral sclerosis

Bacchetti Francesca Bonifacino Tiziana Torazza Carola

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective therapies, characterized by degeneration of motor neurons and muscle atrophy. Mitochondrial dysfunction, oxidative stress, and inflammatory response are pathognomonic signs of ALS. In this scenario, a crucial role is played by the nuclear erythroid-related...

Uploaded on: July 3, 2024
2023 (v1)

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The mGlu5 receptor negative allosteric modulator CTEP as a pharmacological tool to dampen ALS disease progression: in-vivo preclinical studies and clinical perspectives

Milanese Marco Bonifacino Tiziana Balbi Matilde

Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease due to a progressive degeneration of motor neurons (MNs). The aetiology is still largely obscure, and several mechanisms have been proposed, including glutamate (Glu)-mediated excitotoxicity. In this context, group I metabotropic Glu receptors (mGluR1/5) play an active role,...

Uploaded on: July 3, 2024
2023 (v1)

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Reactive phenotype and oxidative stress in i-Astrocytes from patients affected by Amyotrophic Lateral Sclerosis: how the mGluR5 negative allosteric modulator CTEP affects these pathological features

Tessitore Sara Torazza Carola Kumar Mandeep

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Uploaded on: July 3, 2024
2021 (v1)

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In-vivo and in-vitro evidence supporting the role of mGlu5 receptor as a key regulator of glutamate downstream effects in ALS

Milanese Marco Bonifacino Tiziana Torazza Carola

INTRODUCTION. Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease characterised by a progressive degeneration of motor neurons (MNs). The aetiology is still largely obscure, and several mechanisms have been proposed, including glutamate (Glu)-mediated excitotoxicity. In this context, group I metabotropic Glu receptors...

Uploaded on: April 14, 2023
2024 (v1)

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Therapeutic effect of extracellular vesicles derived from mesenchymal stem cells in amyotrophic lateral sclerosis

Francesca Bacchetti Matilde Balbi Giunti Debora

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Uploaded on: July 3, 2024

TORAZZA CAROLA

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