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TORINO , Stephanie

Last name: TORINO

First name: Stephanie

December 30, 2012 (v1)

Journal article

Metadata-only

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway

Robert, Guillaume Jullian, Valérie Jacquel, Arnaud

Simalikalactone E (SkE) is a quassinoid extracted from a widely used Amazonian antimalarial remedy. Although SkE has previously been shown to have cytostatic and/or cytotoxic activities in some tumor cell lines, its mechanism of action has not yet been characterized. We show here that SkE in the high nanomolar range inhibited the growth of...

Uploaded on: December 3, 2022