TORRE G. C.

DNA point mutations of the TSH receptor and of the a subunit of the stimulatory GTP-binding protein (Gsa) have been suggested as major causes of hyperfunctioning thyroid adenomas. However, significant differences in the prevalence of these mutations (from 0.3 to 84%) have been found in different populations. The present study was designed to...

Ten patients with dyspeptic symptoms participated in a double-blind, placebo-controlled, cross-over trial to investigate the effects of pirenzepine, a new antiulcer drug with selective antimuscarinic properties, on the lower esophageal sphincter (LES). Significant decreases in LES Pressure (LESP) were observed ten and twenty minutes after...