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TRAPASSO , Francesco

Last name: TRAPASSO

First name: Francesco

2017 (v1)

Publication

Metadata-only

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis

Bilotta, Anna Dattilo, Vincenzo D'Agostino, Sabrina

PTPRJ is a receptor protein tyrosine phosphatase with tumor suppressor activity. Very little is known about the role of PTPRJ ectodomain, although recently both physiological and synthetic PTPRJ ligands have been identified. A putative shorter spliced variant, coding for a 539 aa protein corresponding to the extracellular N-terminus of PTPRJ,...

Uploaded on: April 14, 2023
2016 (v1)

Publication

Metadata-only

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

Talarico, Cristina Dattilo, Vincenzo D'Antona, Lucia

Glioblastoma multiforme (GBM) is the most aggressive CNS tumor and is characterized by a very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which strongly compromises patients survival. We have recently identified the small molecule SI113, as a potent and selective inhibitor of SGK1, a serine/threonine protein...

Uploaded on: April 14, 2023