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TRAVERSO , Sonia

Last name: TRAVERSO

First name: Sonia

2002 (v1)

Publication

Metadata-only

Mechanisms of block of muscle type CLC chloride channels (Review)

Pusch, Michael Accardi, Alessio Liantonio, Antonella

CLC proteins are a nine-member gene family of Cl- channels that have diverse roles in the plasma membrane and in intracellular organelles. The recent structure determination of bacterial CLC homologues by Dutzler et al. was a breakthrough for the structure-function analysis of CLC channels. This review describes the mechanisms of inhibition of...

Uploaded on: March 27, 2023
2002 (v1)

Publication

Metadata-only

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

Liantonio, Antonella Accardi, Alessio Carbonara, Giuseppe

CLC channels are a gene family of Cl(-) channels that serve a variety of functions, several of which are involved in genetic diseases. Few specific ligands of CLC channels are known that could be useful as pharmacological tools or potential drugs. We synthesized various derivatives of 2-(p-chlorophenoxy)propionic acid, the S(-)-enantiomer of...

Uploaded on: April 14, 2023