T

T

TUCCINARDI , Tiziano

Last name: TUCCINARDI

First name: Tiziano

2015 (v1)

Publication

Metadata-only

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors

Tintori, Cristina La Sala, Giuseppina Vignaroli, Giulia

Fyn is a member of the Src-family of nonreceptor protein−tyrosine kinases. Its abnormal activity has been shown to be related to various human cancers as well as to severe pathologies, such as Alzheimer's and Parkinson's diseases. Herein, a structure-based drug design protocol was employed aimed at identifying novel Fyn inhibitors. Two hits...

Uploaded on: April 14, 2023