2002 (v1)
Publication
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Uploaded on: March 31, 2023
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2004 (v1)Publication
Synthesis and pharmacological screening of new 2-methylthio/2-methanesulfonyl/2-methoxy-5H-[1]benzopyrano[4,3- d]pyrimidines were planned in order to study the effects of the 5-substitution with alkoxy/phenoxy/alkylthio and phenylthio groups both on in vitro antiplatelet and in vivo antinociceptive activities. Antiplatelet activity was assessed...
Uploaded on: April 14, 2023 -
2002 (v1)Publication
A series of 2-methoxy-5H[1]benzopyrano[4,3-d]pyrimidin-5-amines were prepared and screened for their in vitro antiplatelet activity inducing the aggregation by ADP, arachidonic acid (AA) and collagen. In vivo experiments were performed in order to evaluate their antiphlogistic, analgesic and antipyretic activities. Title compounds showed...
Uploaded on: April 14, 2023 -
2007 (v1)Publication
Neutrophil chemotaxis is a complex multistep process that, if upregulated, causes acute inflammation and a no. of autoimmune diseases. The synthesis of pyrazolyl ureas, e.g., I and II (R = 3-benzyl, 3-Ph, 3-iso-Pr), that are potent inhibitors of interleukin-8 (IL-8)-induced neutrophil chemotaxis, is reported. A series of compds., obtained by...
Uploaded on: April 14, 2023